Handgun cartridges offering the highest muzzle energy generally feature large-diameter bullets propelled at significant velocities. For example, cartridges like the .50 Action Express, .475 Linebaugh, and .460 S&W Magnum are often cited for their substantial stopping power. Several factors contribute to a cartridge’s effectiveness, including bullet weight, design, and velocity, as well as the firearm’s barrel length.
The pursuit of increased stopping power has driven cartridge development for decades. Historically, law enforcement and hunters requiring significant terminal ballistics have fueled this demand. A more powerful cartridge can potentially offer a quicker, more humane takedown of game animals or improved self-defense capabilities. However, this potential benefit is often coupled with increased recoil and decreased ammunition capacity. Choosing an appropriate cartridge involves balancing power, controllability, and intended use.