High-pressure handgun ammunition designed for semi-automatic pistols represents a pinnacle of stopping power in a readily available platform. Examples include large-caliber rounds like the .50 Action Express, the .460 S&W Magnum, and the .454 Casull. These cartridges generate significantly higher muzzle energy and velocity compared to more common handgun rounds, resulting in increased terminal ballistic performance.
The development and adoption of such potent cartridges reflect a demand for increased effectiveness in hunting, self-defense, and certain law enforcement applications. The historical progression from smaller calibers to these powerful options demonstrates a continuous effort to improve lethality and stopping power within the constraints of a semi-automatic handgun platform. This pursuit has led to advancements in firearm design and metallurgy to withstand the high pressures generated by these rounds.